Human myxomatous mitral valves exhibit focal expression of cartilage
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چکیده
Results and Conclusions: Myxomatous, but not normal, mitral valves demonstrated sharp focal areas that were abundant in aggrecan, type II collagen, and Sox9. These focal areas co-localized with areas of myxomatous pathologic change on Movat staining. Some cells in these areas had a round and hypertrophic morphology reminiscent of chondrocytes. Runx2 was only weakly present in normal and myxomatous mitral valves. These findings suggest a focal pathologic process in MMVD that mimics chondrogenesis. Carla M. R. Lacerda, Ph.D. a, Holly B. MacLea, D.V.M. , Colleen G. Duncan, D.V.M., Ph.D. , John D. Kisiday, Ph.D., E. Christopher Orton, D.V.M., Ph.D. a
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